{"id":959,"date":"2019-06-07T16:48:22","date_gmt":"2019-06-07T14:48:22","guid":{"rendered":"http:\/\/www-pict.ipbs.fr\/?page_id=959"},"modified":"2022-12-16T15:29:24","modified_gmt":"2022-12-16T14:29:24","slug":"synthese","status":"publish","type":"page","link":"http:\/\/www.pict.ipbs.fr\/index.php\/synthese\/","title":{"rendered":"Synth\u00e8se chimique &#038; peptidique"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"959\" class=\"elementor elementor-959\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-491a281a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"491a281a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5fc0163f\" data-id=\"5fc0163f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c2a27f6 elementor-widget elementor-widget-text-editor\" data-id=\"2c2a27f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<div class=\"wp-block-themeisle-blocks-advanced-columns has-undefined-columns has-desktop-undefined-layout has-tablet-equal-layout has-mobile-equal-layout has-default-gap has-vertical-unset\" id=\"wp-block-themeisle-blocks-advanced-columns-29af697b\" style=\"border-width:0px;border-style:solid;border-color:#000000;border-radius:0px;justify-content:unset\"><div class=\"wp-themeisle-block-overlay\" style=\"opacity:0.5;mix-blend-mode:normal\"><\/div><div class=\"innerblocks-wrap\"><\/div><\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-33800818 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"33800818\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f1b78c3\" data-id=\"4f1b78c3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-487aab0d elementor-widget elementor-widget-heading\" data-id=\"487aab0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Synth\u00e8se chimique<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7645d0 elementor-widget elementor-widget-heading\" data-id=\"7645d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Conception et synth\u00e8se de mol\u00e9cules organiques d\u2019int\u00e9r\u00eat biologique<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-708d0be1 elementor-widget elementor-widget-text-editor\" data-id=\"708d0be1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span>PICT dispose d\u2019une offre de synth\u00e8se donnant acc\u00e8s \u00e0 une large gamme de petites mol\u00e9cules organiques et de peptides d\u2019int\u00e9r\u00eat biologique.<\/span><\/p>\n<p><span>La synth\u00e8se chimique repr\u00e9sente une \u00e9tape cl\u00e9 dans la plupart des programmes de recherche \u00e0 l\u2019interface de la chimie et de la biologie. La production fiable des compos\u00e9s originaux d\u00e9di\u00e9s aux criblages comme aux \u00e9tudes biophysiques et biologiques est toujours un enjeu important. <\/span><\/p>\n<p><span>L&rsquo;objectif est d&rsquo;offrir un service de synth\u00e8se chimique enti\u00e8rement int\u00e9gr\u00e9 aux programmes d&rsquo;identification de ligands mis en \u0153uvre au sein de la plateforme PICT.\u00a0<\/span>Il s\u2019agit, d\u00e8s la mise \u00e0 jour d\u2019une mol\u00e9cule active, de proposer un ensemble coh\u00e9rent d\u2019approches et d\u2019outils chimiques favorisant son d\u00e9veloppement.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74c604e elementor-widget elementor-widget-heading\" data-id=\"74c604e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Offre de service\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62d0c00a elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"62d0c00a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-62d0c00a\" class=\"eael-advance-tabs eael-tabs-horizontal eael-tab-auto-active \" data-tabid=\"62d0c00a\">\n            <div class=\"eael-tabs-nav \">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"1-synthse-chimique\" class=\"active-default eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"1-synthse-chimique-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >1. Synth\u00e8se chimique<\/span>                                                    <\/li>\n                                            <li id=\"2-synthse-peptidique\" class=\" eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"2-synthse-peptidique-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" >2. Synth\u00e8se peptidique<\/span>                                                    <\/li>\n                    \n                                  <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"1-synthse-chimique-tab\" class=\"clearfix eael-tab-content-item active-default\" data-title-link=\"1-synthse-chimique-tab\">\n\t\t\t\t        <div class=\"elementor-element elementor-element-38232d4 elementor-widget elementor-widget-heading\">\n<div class=\"elementor-widget-container\">\n<h5 class=\"elementor-heading-title elementor-size-default\">Synth\u00e8se chimique<\/h5>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-31acbee elementor-widget elementor-widget-text-editor\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-text-editor elementor-clearfix\">\n<p><span>Cette\u00a0prestation de synth\u00e8se organique offre\u00a0une synergie avec le service d\u2019analyse et de purification aussi pr\u00e9sent sur le plateau de Chimie bas\u00e9 au <a href=\"http:\/\/spcmib.univ-tlse3.fr\/\">laboratoire de Synth\u00e8se et Physico-Chimie de Mol\u00e9cules d\u2019Int\u00e9r\u00eat Biologique<\/a> (SPCMIB, UMR CNRS 5068). L\u2019unit\u00e9 de recherche SPCMIB d\u00e9veloppe ses activit\u00e9s dans le domaine de la chimie en lien avec le vivant et la sant\u00e9. Les pistes poursuivies ciblent la conception, la synth\u00e8se et l\u2019\u00e9tude de mol\u00e9cules \u00e0 vis\u00e9es th\u00e9rapeutique (activit\u00e9s anti-infectieuse, anti-canc\u00e9reuse ou anti-inflammatoire), diagnostique (imageries optique, par r\u00e9sonnance magn\u00e9tique ou nucl\u00e9aire) ou th\u00e9ranostique.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<section class=\"elementor-element elementor-element-51db06f elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-inner-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-cc559b0 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-68ba6a5 elementor-widget elementor-widget-image\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-image\"><img fetchpriority=\"high\" decoding=\"async\" src=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese1-small-300x200.jpg\" alt=\"\" class=\"alignnone size-medium wp-image-1224\" width=\"300\" height=\"200\" srcset=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese1-small-300x200.jpg 300w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese1-small-360x240.jpg 360w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese1-small.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-b9a58f9 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-f38562b elementor-widget elementor-widget-image\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-image\"><img decoding=\"async\" src=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthesis-2-small-2-300x200.jpg\" alt=\"\" class=\"alignnone size-medium wp-image-1225\" width=\"300\" height=\"200\" srcset=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthesis-2-small-2-300x200.jpg 300w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthesis-2-small-2-360x240.jpg 360w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthesis-2-small-2.jpg 400w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<div class=\"elementor-element elementor-element-d0f52e9 elementor-widget elementor-widget-text-editor\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-text-editor elementor-clearfix\">\n<ul>\n<li>Synth\u00e8se de ligands peu accessibles.<\/li>\n<li>Exploration de l\u2019espace chimique.<\/li>\n<li>Exploitation de fragments.<\/li>\n<li>D\u00e9veloppement de sondes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<section class=\"elementor-element elementor-element-2268bbf elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-inner-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-4aec925 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-6adccae elementor-align-center elementor-widget elementor-widget-button\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-button-wrapper\"><a href=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2021\/01\/Plateau-de-Chimie-Synthese-Chimique.pdf\" target=\"_blank\" class=\"elementor-button-link elementor-button elementor-size-sm\" rel=\"noopener\"><span class=\"elementor-button-content-wrapper\"><span class=\"elementor-button-icon elementor-align-icon-left\"><i class=\"fa fa-file-pdf-o\"><\/i><\/span><span class=\"elementor-button-text\">en savoir plus<\/span><\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-23e2039 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-78d1fad elementor-align-center elementor-widget elementor-widget-button\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-button-wrapper\"><a href=\"mailto:spcmib.synthese@univ-tlse3.fr\" class=\"elementor-button-link elementor-button elementor-size-sm\"><span class=\"elementor-button-content-wrapper\"><span class=\"elementor-button-icon elementor-align-icon-left\"><i class=\"far fa-address-book\"><\/i><\/span><span class=\"elementor-button-text\">contact<\/span><\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>                    <\/div>\n\t\t        \n                    <div id=\"2-synthse-peptidique-tab\" class=\"clearfix eael-tab-content-item \" data-title-link=\"2-synthse-peptidique-tab\">\n\t\t\t\t        <section class=\"elementor-element elementor-element-2b3ac26 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-top-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-24990ea elementor-column elementor-col-100 elementor-top-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-38232d4 elementor-widget elementor-widget-heading\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-element elementor-element-580586a7 elementor-widget elementor-widget-heading\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-element elementor-element-580586a7 elementor-widget elementor-widget-heading\">\n<div class=\"elementor-widget-container\">\n<section class=\"elementor-element elementor-element-2b3ac26 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-top-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-24990ea elementor-column elementor-col-100 elementor-top-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-38232d4 elementor-widget elementor-widget-heading\">\n<div class=\"elementor-widget-container\">\n<h5 class=\"elementor-heading-title elementor-size-default\">Synth\u00e8se de peptides standards et originaux<\/h5>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-ac02c36 elementor-widget elementor-widget-text-editor\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-text-editor elementor-clearfix\">\n<p>Le plateau de synth\u00e8se peptidique propose :<\/p>\n<ul>\n<li>la synth\u00e8se de peptides standards de 5 \u00e0 45 acides amin\u00e9s<\/li>\n<\/ul>\n<ol>\n<li>des peptides marqu\u00e9s au 13C et\/ou 15N et\/ou 2H, les peptides amylo\u00efdes, cycliques, fluorescents,\u00a0glycosyl\u00e9s, phosphoryl\u00e9s,\u00a0hydrophobes (segments transmembranaires), avec des\u00a0acides amin\u00e9s d\u00e9riv\u00e9s (isom\u00e8res D, NMeAla, Aib, <span>b<\/span>Ala, \u00a0dTyr\u2026) ou insatur\u00e9s pour un marquage au tritium<\/li>\n<li>des peptides modifi\u00e9s aux extr\u00e9mit\u00e9s (ac\u00e9tylation, acylation, amidation, biotinylation)<\/li>\n<li>la production d\u2019antig\u00e8nes (d\u00e9termination des s\u00e9quences potentiellement antig\u00e9niques dans une prot\u00e9ine\u00a0: synth\u00e8se des peptides)<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<section class=\"elementor-element elementor-element-363c3d5 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-inner-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-ce79bc0 elementor-column elementor-col-100 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-9daa92b elementor-widget elementor-widget-image\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-image\"><img decoding=\"async\" src=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese-2-300x200.jpg\" alt=\"\" class=\"alignnone size-medium wp-image-1198\" width=\"300\" height=\"200\" srcset=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese-2-300x200.jpg 300w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese-2-768x513.jpg 768w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese-2-360x240.jpg 360w, http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2020\/01\/synthese-2.jpg 899w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<div class=\"elementor-element elementor-element-1ddcf49 elementor-widget elementor-widget-text-editor\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-text-editor elementor-clearfix\">\n<ul>\n<li>la synth\u00e8se d\u2019une banque de peptides (t\u00e9tra-peptides) comme outil de criblage<\/li>\n<\/ul>\n<ul>\n<li>la synth\u00e8se de peptides \u00e0 fa\u00e7on.<\/li>\n<\/ul>\n<p>La synth\u00e8se est r\u00e9alis\u00e9e en phase solide, suivant la strat\u00e9gie Fmoc.<\/p>\n<p>Apr\u00e8s purification et contr\u00f4les, les peptides sont remis sous forme lyophilis\u00e9e selon les conditions convenues, un spectre de masse du peptide ainsi qu\u2019un profil HPLC seront remis au client.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<section class=\"elementor-element elementor-element-2268bbf elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-section elementor-inner-section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-row\">\n<div class=\"elementor-element elementor-element-4aec925 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-6adccae elementor-align-center elementor-widget elementor-widget-button\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-button-wrapper\"><a href=\"http:\/\/www.pict.ipbs.fr\/wp-content\/uploads\/2021\/01\/Plateau-de-Synthase-Peptidique.pdf\" target=\"_blank\" class=\"elementor-button-link elementor-button elementor-size-sm\" rel=\"noopener\"><span class=\"elementor-button-content-wrapper\"><span class=\"elementor-button-icon elementor-align-icon-left\"><i class=\"fa fa-file-pdf-o\"><\/i><\/span><span class=\"elementor-button-text\">en savoir plus<\/span><\/span><\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-23e2039 elementor-column elementor-col-50 elementor-inner-column\">\n<div class=\"elementor-column-wrap  elementor-element-populated\">\n<div class=\"elementor-widget-wrap\">\n<div class=\"elementor-element elementor-element-78d1fad elementor-align-center elementor-widget elementor-widget-button\">\n<div class=\"elementor-widget-container\">\n<div class=\"elementor-button-wrapper\"><span class=\"elementor-button-content-wrapper\"><a href=\"mailto:Nathalie.Doncescu@ipbs.fr\" class=\"elementor-button-link elementor-button elementor-size-sm\"><span class=\"elementor-button-icon elementor-align-icon-left\"><i class=\"far fa-address-book\"><\/i><\/span><span class=\"elementor-button-text\">contact<\/span><\/a><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-033f782 elementor-widget elementor-widget-text-editor\" data-id=\"033f782\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>1.\u00a0 Conception, synth\u00e8se et purification de petites mol\u00e9cules organiques (synth\u00e8se\u00a0chimique)<\/strong><\/p>\n<p>Une mol\u00e9cule commerciale est inabordable ou une mol\u00e9cule publi\u00e9e est indisponible. La prestation concerne la synth\u00e8se des compos\u00e9s non disponibles commercialement pour en d\u00e9livrer une quantit\u00e9 convenue et\/ou en d\u00e9velopper une voie de synth\u00e8se multi-\u00e9tapes transf\u00e9rable.<\/p>\n<p>La d\u00e9couverte de nouveaux ch\u00e2ssis mol\u00e9culaires actifs appellent des \u00e9tudes compl\u00e9mentaires. L&rsquo;offre de service porte sur la synth\u00e8se d\u2019un nombre d\u00e9fini de d\u00e9riv\u00e9s proches des ch\u00e2ssis mol\u00e9culaires actifs par post-fonctionnalisation ou synth\u00e8se en s\u00e9rie.<\/p>\n<p>Un ou plusieurs fragments actifs identifi\u00e9s par criblage sont s\u00e9lectionn\u00e9s pour construire une mol\u00e9cule de taille et d\u2019affinit\u00e9 sup\u00e9rieures. La g\u00e9n\u00e9ration d\u2019un nombre d\u00e9fini de compos\u00e9s inspir\u00e9s des fragments de d\u00e9part est propos\u00e9e en prestation.<\/p>\n<p>L&rsquo;identification d&rsquo;un ligand requi\u00e8re des \u00e9tudes de distribution cellulaire ou d&rsquo;identification de cible. La prestation consiste en pr\u00e9paration de sondes photoluminescentes, incluant leur caract\u00e9risation photophysique fine, ou de sondes clickables, portant ou non un groupement de marquage par photo-affinit\u00e9.<\/p>\n<p><\/p>\n<p><strong>2. Synth\u00e8se et purification de peptides standards et \u00e0 fa\u00e7on (synth\u00e8se peptidique)<\/strong><\/p>\n<p><span>Le service de synth\u00e8se peptidique offre des peptides \u00e0 activit\u00e9s biologiques de qualit\u00e9. Ces peptides sont de puissants outils qui trouvent de nombreuses applications dans divers projets de recherche ou de d\u00e9veloppement comme : le criblage de ligands \u00e0 vis\u00e9e pharmaceutique, l\u2019\u00e9tude des relations structure\/fonction des prot\u00e9ines\u00a0<\/span><span>ou <\/span><span>en immunologie (production d\u2019anticorps).<\/span><span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7efb262f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7efb262f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Synth\u00e8se chimique Conception et synth\u00e8se de mol\u00e9cules organiques d\u2019int\u00e9r\u00eat biologique PICT dispose d\u2019une offre de synth\u00e8se donnant acc\u00e8s \u00e0 une large gamme de petites mol\u00e9cules organiques et de peptides d\u2019int\u00e9r\u00eat biologique. La synth\u00e8se chimique repr\u00e9sente une \u00e9tape cl\u00e9 dans la plupart des programmes de recherche \u00e0 l\u2019interface de la chimie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":230,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/template-fullwidth.php","meta":{"footnotes":""},"class_list":["post-959","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/pages\/959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/comments?post=959"}],"version-history":[{"count":61,"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/pages\/959\/revisions"}],"predecessor-version":[{"id":1908,"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/pages\/959\/revisions\/1908"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/media\/230"}],"wp:attachment":[{"href":"http:\/\/www.pict.ipbs.fr\/index.php\/wp-json\/wp\/v2\/media?parent=959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}